Conference
CD73 expression in primary and metastatic renal cell carcinoma (RCC).
Abstract
643
Background: Agents targeting the PD-1 pathway have improved outcomes in RCC. CD73 may be an additional mechanism which tumors can exploit for immune evasion. It is regulated by hypoxia inducible factor (HIF) and converts AMP to adenosine. The resulting increase in extracellular adenosine can inhibit T-cell effector function. We evaluated CD73 expression in primary and metastatic tumor samples in patients with RCC. Methods: …
Authors
Tripathi A; Johnston SE; Zhao YD; Hassan O; Thompson LF; Lalani A-KA; Wei XX; Giannakis M; Signoretti S; Choueiri TK
Volume
36
Pagination
pp. 643-643
Publisher
American Society of Clinical Oncology (ASCO)
Publication Date
February 20, 2018
DOI
10.1200/jco.2018.36.6_suppl.643
Conference proceedings
Journal of Clinical Oncology
Issue
6_suppl
ISSN
0732-183X