Chapter 3 Systemic Juvenile Idiopathic Arthritis

The diagnosis of systemic juvenile idiopathic arthritis (sJIA) requires the rigorous exclusion of a broad range of conditions, particularly infections and malignancies, and in the younger infants, the autoinflammatory syndromes. The clinician should be vigilant for both the common and less common systemic manifestations of the disease. Macrophage activation syndrome (MAS) is a potentially fatal complication that requires prompt diagnosis and …