Chapter 4 Cell Surface GRP78 A Novel Regulator of Tissue Factor Procoagulant Activity

The Glucose Regulated Protein 78,000 (GRP78) is an endoplasmic reticulum (ER)-resident chaperone responsible for ensuring that newly synthesized polypeptides entering the ER are properly folded into functional proteins. Under normal physiological conditions, GRP78 associates with IRE-1, ATF-6 and PERK, ER membrane proteins that modulate the unfolded protein response (UPR). Following the accumulation of misfolded/unfolded proteins within the ER, …