A309 ANTIBIOTIC DRIVEN CHANGES IN GUT MOTILITY HIGHLIGHT DIRECT MODULATION OF ENTERIC NERVOUS SYSTEM

The microbiome-gut-brain axis is a bidirectional network that influences brain chemistry and behaviour. Antibiotics are known to alter several aspects of gut-brain signaling but the underlying mechanisms remain equivocal. As prior assessments of these mechanisms have been limited to changes in gut microbiota, we hypothesized that antibiotics may directly modulate neurons and neural reflexes. To identify whether transient exposure of the …