Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

The cover picture shows the regions (shades of blue) on human lysosomal glucocerebrosidase (green) that undergo a significant reduction in hydrogen–deuterium exchange (denoted by loss of blurriness) upon binding a 2,4‐diamino‐5‐substituted quinazoline (MWP; red). MWP was identified in a high‐throughput screen of the Maybridge library of 50 000 small molecule drug‐like compounds (grey structures) for inhibitors. The confocal images immediately …