Circulating Blasts Are Associated with High Levels of vWF and Thrombin Activation in Children with Newly Diagnosed ALL.

Abstract Background: Children with acute lymphoblastic leukemia (ALL) are known to have thrombin activation at diagnosis. However, the pathophysiology of thrombin generation and the impact of therapy on thrombin activation are so far unknown. Steroids are shown to induce prothrombotic state by increasing prothrombotic factors and reducing fibrinolytic potential. The investigational window on DFCI 05-01 protocol offered an …