Journal article
In vivo hippocampal cornu ammonis 1–3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes
Abstract
OBJECTIVE: Previous positron emission tomography (PET) studies using [11 C]ABP688 show reduced metabotropic glutamate receptor type 5 (mGluR5) allosteric binding site availability in the epileptogenic hippocampus of mesial temporal lobe epilepsy (MTLE) patients. However, the link between mGluR5 abnormalities and postsurgical outcomes remains unclear. Here, we test whether reduced PET [11 C]ABP688 binding in cornu ammonis (CA) sectors more …
Authors
Lam J; DuBois JM; Rowley J; Rousset OG; González‐Otárula KA; Soucy J; Massarweh G; Hall JA; Guiot M; Zimmermann M
Journal
Epilepsia, Vol. 62, No. 7, pp. 1559–1568
Publisher
Wiley
Publication Date
July 2021
DOI
10.1111/epi.16952
ISSN
0013-9580
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedCA1 Region, HippocampalCA3 Region, HippocampalEpilepsy, Temporal LobeFemaleFluorodeoxyglucose F18Glutamic AcidHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeurosurgical ProceduresOximesPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, Kainic AcidTreatment OutcomeYoung Adult