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A well plate–based multiplexed platform for...
Journal article

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

Abstract

Owing to their high spatiotemporal precision and adaptability to different host cells, organ-on-a-chip systems are showing great promise in drug discovery, developmental biology studies and disease modeling. However, many current micro-engineered biomimetic systems are limited in technological application because of culture media mixing that does not allow direct incorporation of techniques from stem cell biology, such as organoids. Here, we …

Authors

Lai BFL; Lu RXZ; Davenport Huyer L; Kakinoki S; Yazbeck J; Wang EY; Wu Q; Zhang B; Radisic M

Journal

Nature Protocols, Vol. 16, No. 4, pp. 2158–2189

Publisher

Springer Nature

Publication Date

April 2021

DOI

10.1038/s41596-020-00490-1

ISSN

1754-2189