Journal article
Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients
Abstract
Intestinal epithelial cell tight junctions (TJs) contribute to the integrity of the intestinal barrier allowing for control of the physical barrier between external antigens or bacterial products and the internal environment. Zonula occludens-1 (ZO-1) is a protein that modulates intestinal TJs, and serum levels of ZO-1 has been suggested as a biomarker of disrupted barrier function in humans. Previous studies suggested that increased intestinal …
Authors
Power N; Turpin W; Espin-Garcia O; Smith MI; Consortium TCGPR; Croitoru K
Journal
Frontiers in Physiology, Vol. 12, ,
Publisher
Frontiers
DOI
10.3389/fphys.2021.645303
ISSN
1664-042X