Journal article
Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle
Abstract
Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼ 3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼-25%). These results …
Authors
Walsh JJ; Edgett BA; Tschakovsky ME; Gurd BJ
Journal
Applied Physiology Nutrition and Metabolism, Vol. 40, No. 1, pp. 96–98
Publisher
Canadian Science Publishing
Publication Date
January 2015
DOI
10.1139/apnm-2014-0290
ISSN
1715-5312
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultBicyclingBrain-Derived Neurotrophic FactorCross-Over StudiesExerciseFastingGene Expression RegulationHumansMaleMotor ActivityMuscle, SkeletalOxygen ConsumptionPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhysical ExertionQuadriceps MuscleRNA, MessengerStress, PhysiologicalTranscription FactorsUp-RegulationYoung Adult