Lipid oxidation during thermogenesis in high-altitude deer mice (Peromyscus maniculatus)

When at their maximum thermogenic capacity (cold-induced V̇o_2max), small endotherms reach levels of aerobic metabolism as high, or even higher, than running V̇o_2max. How these high rates of thermogenesis are supported by substrate oxidation is currently unclear. The appropriate utilization of metabolic fuels that could sustain thermogenesis over extended periods may be important for survival in cold environments, like high altitude. Previous …