Pharmacokinetic implications of dosing emicizumab based on vial size: A simulation study

INTRODUCTION: Emicizumab is dosed as mg/kg and, according to the label, any unused drug left in the vial(s) must be discarded, thereby wasting expensive resources. The aim of this study was to use population pharmacokinetics to illustrate the implications of changing the dosing interval to avoid wastage. METHODS: We used a previously published emicizumab PopPK model after extending its validation to children. We simulated PK parameters for …