Journal article
Increase of peripheral T regulatory cells during remission induction with cyclophosphamide in active systemic lupus erythematosus
Abstract
BACKGROUND: Cyclophosphamide efficacy in lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE) is probably mediated by a non-specific ablation of reactive lymphocytes. However, little is known in regard to its effect on T regulatory cells (Tregs) in such patients, which was the aim of this study.
PATIENTS AND METHODS: Ten Caucasian lupus patients were included, six with LN classes IV-V (mean age 33.8 ± 8.8 years) and …
Authors
Tselios K; Sarantopoulos A; Gkougkourelas I; Papagianni A; Boura P
Journal
International Journal of Rheumatic Diseases, Vol. 17, No. 7, pp. 790–795
Publisher
Wiley
Publication Date
September 2014
DOI
10.1111/1756-185x.12500
ISSN
1756-1841
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultBiomarkersCyclophosphamideFemaleForkhead Transcription FactorsHumansImmunologic FactorsInterleukin-2 Receptor alpha SubunitLupus Erythematosus, SystemicLupus NephritisLupus Vasculitis, Central Nervous SystemMalePulse Therapy, DrugRemission InductionT-Lymphocytes, RegulatoryTime FactorsTreatment OutcomeUp-Regulation