Journal article
ETS-Domain Transcription Factor Elk-1 Regulates Stemness Genes in Brain Tumors and CD133+ BrainTumor-Initiating Cells
Abstract
Elk-1, a member of the ternary complex factors (TCFs) within the ETS (E26 transformation-specific) domain superfamily, is a transcription factor implicated in neuroprotection, neurodegeneration, and brain tumor proliferation. Except for known targets, c-fos and egr-1, few targets of Elk-1 have been identified. Interestingly, SMN, SOD1, and PSEN1 promoters were shown to be regulated by Elk-1. On the other hand, Elk-1 was shown to regulate the …
Authors
Sogut MS; Venugopal C; Kandemir B; Dag U; Mahendram S; Singh S; Gulfidan G; Arga KY; Yilmaz B; Kurnaz IA
Journal
Journal of Personalized Medicine, Vol. 11, No. 2,
Publisher
MDPI
DOI
10.3390/jpm11020125
ISSN
2075-4426