Journal article
IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma
Abstract
BackgroundAsthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from pandemic H1N1 (pH1N1) viral infection and whether blockade of interleukin-4 receptor α (IL-4Rα), a critical mediator of Th2 signalling, improved their outcomes.MethodsMale BALB/c mice were intranasally …
Authors
Shahangian K; Ngan DA; Chen HHR; Oh Y; Tam A; Wen J; Cheung C; Knight DA; Dorscheid DR; Hackett TL
Journal
Respiratory Research, Vol. 22, No. 1,
Publisher
Springer Nature
Publication Date
December 2021
DOI
10.1186/s12931-021-01669-0
ISSN
1465-9921