Journal article
The migration of metastatic breast cancer cells is regulated by matrix stiffness via YAP signalling
Abstract
Matrix stiffness is a driver of breast cancer progression and mechanosensitive transcriptional activator YAP plays an important role in this process. However, the interplay between breast cancer and matrix stiffness, and the significance of this interplay remained largely unknown. Here, we showed an increase in YAP nuclear localization and a higher proliferation rate in both highly metastatic MDA-MB-231 cells and the non-metastatic counterpart …
Authors
Chen W; Park S; Patel C; Bai Y; Henary K; Raha A; Mohammadi S; You L; Geng F
Journal
Heliyon, Vol. 7, No. 2,
Publisher
Elsevier
Publication Date
2 2021
DOI
10.1016/j.heliyon.2021.e06252
ISSN
1879-4378