Journal article
Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance
Abstract
Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity. An obesity‐promoting high‐fat diet (HFD) increased NOD2 in hepatocytes and adipocytes, and NOD2−/− mice have increased adipose tissue and liver inflammation and exacerbated insulin resistance …
Authors
Denou E; Lolmède K; Garidou L; Pomie C; Chabo C; Lau TC; Fullerton MD; Nigro G; Zakaroff‐Girard A; Luche E
Journal
EMBO Molecular Medicine, Vol. 7, No. 3, pp. 259–274
Publisher
Springer Nature
Publication Date
March 2015
DOI
10.15252/emmm.201404169
ISSN
1757-4676