Concepts and perspectives on peptide-based immunotherapy in allergy

Allergen-specific T cells play a key role in the patho-genesis of allergic diseases through provision of help for allergen-specific B cells and control of inflammatory responses. Allergen immunotherapy using intact allergen proteins (given either sub-cutaneously or sublingually) is clinically effective and demonstrates enduring efficacy (i. e., disease modifying). However, the requirement for monthly injections or daily sublingual …