Journal article
AMPK mediates energetic stress‐induced liver GDF15
Abstract
Growth differentiating factor-15 (GDF15) is an emerging target for the treatment of obesity and metabolic disease partly due to its ability to suppress food intake. GDF15 expression and secretion are thought to be regulated by a cellular integrated stress response, which involves endoplasmic reticulum (ER) stress. AMPK is another cellular stress sensor, but the relationship between AMPK, ER stress, and GDF15 has not been assessed in vivo. …
Authors
Townsend LK; Weber AJ; Day EA; Shamshoum H; Shaw SJ; Perry CGR; Kemp BE; Steinberg GR; Wright DC
Journal
The FASEB Journal, Vol. 35, No. 1,
Publisher
Wiley
Publication Date
January 2021
DOI
10.1096/fj.202000954r
ISSN
0892-6638