Conference
Correlation of Bridging and Lymphodepleting Chemotherapy with Clinical Outcomes in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated with Tisagenlecleucel
Abstract
Background: Tisagenlecleucel is an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy that is approved for adult patients (pts) with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). In the phase 2 JULIET trial, pts could receive bridging therapy (BT), when needed, to permit flexibility in scheduling and maintain disease control. Lymphodepleting chemotherapy (LDC) was started 5-14 days prior to CAR-T cell infusion. …
Authors
Andreadis C; Tam CS; Borchmann P; Jaeger U; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Foley SR
Volume
134
Publisher
American Society of Hematology
Publication Date
November 13, 2019
DOI
10.1182/blood-2019-124492
Conference proceedings
Blood
Issue
Supplement_1
ISSN
0006-4971