Conference
The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal
Abstract
Background:
Acute myeloid leukemia (AML) is thought to be sustained by sub-populations of leukemia stem cells (LSCs), which possess the capacity for self-renewal and differentiation and are believed to be responsible for disease initiation, relapse and chemoresistance. There is therefore an urgent need to develop therapies that target the LSC population to achieve effective AML treatment. To date there has been limited success …
Authors
Liu L; Vujovic A; Xu J; Hope K; Lu Y
Volume
134
Publisher
American Society of Hematology
Publication Date
November 13, 2019
DOI
10.1182/blood-2019-126287
Conference proceedings
Blood
Issue
Supplement_1
ISSN
0006-4971