Journal article
Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
Abstract
BACKGROUND & AIMS: Altered gut microbiota composition and function have been associated with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and mechanisms remain unknown.
METHODS: We applied 16S ribosomal RNA gene sequencing, shotgun metagenomic sequencing, in vitro functional assays, and gnotobiotic colonizations to define the microbial composition and function in fecal samples obtained from a cohort of …
Authors
Galipeau HJ; Caminero A; Turpin W; Bermudez-Brito M; Santiago A; Libertucci J; Constante M; Garay JAR; Rueda G; Armstrong S
Journal
Gastroenterology, Vol. 160, No. 5, pp. 1532–1545
Publisher
Elsevier
Publication Date
4 2021
DOI
10.1053/j.gastro.2020.12.004
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAnimalsBacteriaBacterial ProteinsBiomarkersCase-Control StudiesChildColitis, UlcerativeDisease Models, AnimalFecal Microbiota TransplantationFecesFemaleGastrointestinal MicrobiomeGerm-Free LifeHumansMaleMetagenomeMetagenomicsMice, Inbred C57BLPeptide HydrolasesPredictive Value of TestsProspective StudiesProtease InhibitorsProteolysisReproducibility of ResultsRibotypingYoung AdultMice