Journal article
Construction of a Novel Multigene Panel Potently Predicting Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma
Abstract
We observed associations of IQGAP1 downregulation with poor overall survival (OS) in clear cell renal cell carcinoma (ccRCC). Differentially expressed genes (DEGs, n = 611) were derived from ccRCCs with (n = 111) and without IQGAP1 (n = 397) reduction using the TCGA PanCancer Atlas ccRCC dataset. These DEGs exhibit downregulations of immune response and upregulations of DNA damage repair pathways. Through randomization of the TCGA dataset into …
Authors
Lin X; Kapoor A; Gu Y; Chow MJ; Peng J; Major P; Tang D
Journal
Cancers, Vol. 12, No. 11,
Publisher
MDPI
DOI
10.3390/cancers12113471
ISSN
2072-6694