Journal article
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation
Abstract
Sperm-associated antigen 5 (SPAG5) is an important driver of the cell mitotic spindle required for chromosome segregation and progression into anaphase. SPAG5 has been identified as an important proliferation marker and chemotherapy-sensitivity predictor, especially in estrogen receptor-negative breast cancer subtypes. Here, we report that SPAG5 is a direct target of miR-10b-3p, and its aberrantly high expression associates with poor …
Authors
Canu V; Donzelli S; Sacconi A; Lo Sardo F; Pulito C; Bossel N; Di Benedetto A; Muti P; Botti C; Domany E
Journal
Cell Death & Differentiation, Vol. 28, No. 5, pp. 1493–1511
Publisher
Springer Nature
Publication Date
May 2021
DOI
10.1038/s41418-020-00677-9
ISSN
1350-9047