Journal article
Selection and Characterization of an RNA‐Cleaving DNAzyme Activated by Legionella pneumophila
Abstract
Legionella pneumophila is a deadly bacterial pathogen that has caused numerous Legionnaires' disease outbreaks, where cooling towers were the most common source of exposure. Bacterial culturing is used for L. pneumophila detection, but this method takes approximately 10 days to complete. In this work, an RNA-cleaving fluorogenic DNAzyme, named LP1, was isolated. Extensive characterization revealed that LP1 is reactive with multiple infectious …
Authors
Rothenbroker M; McConnell EM; Gu J; Urbanus ML; Samani SE; Ensminger AW; Filipe CDM; Li Y
Journal
Angewandte Chemie International Edition, Vol. 60, No. 9, pp. 4782–4788
Publisher
Wiley
Publication Date
February 23, 2021
DOI
10.1002/anie.202012444
ISSN
1433-7851