Journal article
Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion
Abstract
BACKGROUND: Multimerin 1 (human: MMRN1, mouse: Mmrn1) is a homopolymeric, adhesive, platelet and endothelial protein that binds to von Willebrand factor and enhances platelet adhesion to fibrillar collagen ex vivo.
OBJECTIVES: To examine the impact of Mmrn1 deficiency on platelet adhesive function, and the molecular motifs in fibrillar collagen that bind MMRN1 to enhance platelet adhesion.
Authors
Leatherdale A; Parker D; Tasneem S; Wang Y; Bihan D; Bonna A; Hamaia SW; Gross PL; Ni H; Doble BW
Journal
Journal of Thrombosis and Haemostasis, Vol. 19, No. 2, pp. 547–561
Publisher
Elsevier
Publication Date
2 2021
DOI
10.1111/jth.15171
ISSN
1538-7933