Prevalence of pyridoxine dependent seizures in south Indian children with early onset intractable epilepsy: A hospital based prospective study

OBJECTIVES: Determine the prevalence of pyridoxine dependent seizures in children less than 16 years of age attending a teaching hospital in south India with early onset (before 3 years) intractable epilepsy of unknown aetiology, using the criteria proposed by Baxter. METHOD: A cohort of 81 children, fulfilling the above criteria, was given 15 mg/kg/day of oral pyridoxine for 7 days. Non-responders were given a further 7-day trial of 30 …