Journal article
Fine Mapping of the Insulin-Induced Gene 2 Identifies a Variant Associated With LDL Cholesterol and Total Apolipoprotein B Levels
Abstract
BACKGROUND: In a whole-genome scan, a single nucleotide polymorphism (SNP) (rs7566605) upstream of the insulin-induced gene 2 (INSIG2) was shown to influence body mass index and obesity in the Framingham Heart Study, with replication of these results in an additional 4 of 5 studies. However, other studies could not replicate the association. Because INSIG2 plays an important role in cholesterol biosynthesis, we hypothesized that human INSIG2 …
Authors
Do R; Bailey SD; Paré G; Montpetit A; Desbiens K; Hudson TJ; Yusuf S; Bouchard C; Gaudet D; Pérusse L
Journal
Circulation Genomic and Precision Medicine, Vol. 3, No. 5, pp. 454–461
Publisher
Wolters Kluwer
Publication Date
October 2010
DOI
10.1161/circgenetics.109.917039
ISSN
1942-325X