Journal article
Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies
Abstract
The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
Authors
McNulty J; Babu Dokuburra C; D'Aiuto L; Demers M; McClain L; Piazza P; Williamson K; Zheng W; Nimgaonkar VL
Journal
Bioorganic & Medicinal Chemistry Letters, Vol. 30, No. 24,
Publisher
Elsevier
Publication Date
December 2020
DOI
10.1016/j.bmcl.2020.127559
ISSN
0960-894X