Journal article
Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review
Abstract
Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Our systematic review of 175 noninferiority antibiotic trials found these scenarios to be rare.
Authors
Bai AD; Komorowski AS; Lo CKL; Tandon P; Li XX; Mokashi V; Cvetkovic A; Findlater A; Liang L; Loeb M
Journal
Antimicrobial Agents and Chemotherapy, Vol. 64, No. 11, pp. 10.1128/aac.01597–10.1128/aac.01520
Publisher
American Society for Microbiology
Publication Date
October 20, 2020
DOI
10.1128/aac.01597-20
ISSN
0066-4804