Journal article
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control
Abstract
Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose-responsive hepatokine and regulator of glucose homeostasis. Acute intraperitoneal administration of SMOC1 improved glycemic control and insulin sensitivity in mice without changes in insulin secretion. SMOC1 exerted its favorable glycemic …
Authors
Montgomery MK; Bayliss J; Devereux C; Bezawork-Geleta A; Roberts D; Huang C; Schittenhelm RB; Ryan A; Townley SL; Selth LA
Journal
Science Translational Medicine, Vol. 12, No. 559,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
September 2, 2020
DOI
10.1126/scitranslmed.aaz8048
ISSN
1946-6234