Journal article
Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection
Abstract
BACKGROUND & AIMS: Hyperplasia of mucin-secreting intestinal goblet cells accompanies a number of enteric infections, including infections by nematode parasites. Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection.
METHODS: Resistant (BALB/c, C57BL/6), susceptible (AKR), and Muc2-deficient …
Authors
Hasnain SZ; Wang H; Ghia J; Haq N; Deng Y; Velcich A; Grencis RK; Thornton DJ; Khan WI
Journal
Gastroenterology, Vol. 138, No. 5, pp. 1763–1771.e5
Publisher
Elsevier
Publication Date
May 2010
DOI
10.1053/j.gastro.2010.01.045
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateAnimalsDisease Models, AnimalEnergy MetabolismGoblet CellsImmunity, InnateImmunity, MucosalIntestinal Diseases, ParasiticMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, SCIDMucin 5ACMucin-2PermeabilitySpecies SpecificityTh2 CellsTime FactorsTrichuriasisTrichuris