Journal article
Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study design and methodology for an international, adaptive Bayesian randomized controlled trial
Abstract
BACKGROUND: Mortality from COVID-19 is high among hospitalized patients and effective therapeutics are lacking. Hypercoagulability, thrombosis and hyperinflammation occur in COVID-19 and may contribute to severe complications. Therapeutic anticoagulation may improve clinical outcomes through anti-thrombotic, anti-inflammatory and anti-viral mechanisms. Our primary objective is to evaluate whether therapeutic-dose anticoagulation with …
Authors
Houston BL; Lawler PR; Goligher EC; Farkouh ME; Bradbury C; Carrier M; Dzavik V; Fergusson DA; Fowler RA; Galanaud J-P
Journal
Clinical Trials, Vol. 17, No. 5, pp. 491–500
Publisher
SAGE Publications
Publication Date
October 2020
DOI
10.1177/1740774520943846
ISSN
1740-7745