In vitro investigation of potential application of pH-sensitive poly(vinylidene fluoride)–poly(acrylic acid) pore-filled membranes for controlled drug release in ruminant animals

The potential application of the developed membranes on controlled drug release in ruminant animals was explored by studying the membrane performance for a model drug, salicylic acid, in both a pressure-driven system and a diffusion dialysis system. The rejection of salicylic acid (83%) was much higher at pH neutral than that at pH acidic (5%). The permeability at pH neutral (0.84×10−7 to 4.35×10−7m/s) was much lower than that at pH acidic …