Journal article
Effect of Shear Stresses on Adenovirus Activity and Aggregation during Atomization To Produce Thermally Stable Vaccines by Spray Drying
Abstract
Considering the substantive potential benefits of thermally stable dry powder vaccines to public health, causes for inactivation of their sensitive viral vectors during preparation require intensive study. The focus of this work was atomization of suspensions containing encapsulating excipients and a human type 5 adenovirus, involving a detailed investigation of shear stresses in the nozzle of a spray dryer. Samples were sprayed at 25 °C into …
Authors
Morgan BA; Manser M; Jeyanathan M; Xing Z; Cranston ED; Thompson MR
Journal
ACS Biomaterials Science & Engineering, Vol. 6, No. 7, pp. 4304–4313
Publisher
American Chemical Society (ACS)
Publication Date
July 13, 2020
DOI
10.1021/acsbiomaterials.0c00317
ISSN
2373-9878