Journal article
Tranexamic acid and rosuvastatin in patients at risk of cardiovascular events after noncardiac surgery: a pilot of the POISE-3 randomized controlled trial
Abstract
BackgroundSurgical bleeding is associated with postoperative cardiovascular complications. The efficacy and safety of tranexamic acid (TXA) in noncardiac surgery are still uncertain. Statins may prevent perioperative cardiovascular complications. We conducted a pilot to assess the feasibility of a perioperative trial of TXA and rosuvastatin.MethodsUsing a factorial design, we randomized patients at cardiovascular risk undergoing noncardiac …
Authors
Marcucci M; Duceppe E; Le Manach Y; Kearon C; Eikelboom JW; Pohl K; Vincent J; Darvish-Kazem S; Srinathan SK; Neary JDD
Journal
Pilot and Feasibility Studies, Vol. 6, No. 1,
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1186/s40814-020-00643-9
ISSN
2055-5784