Effect of secretagogues and barium ion on resting frog stomach

Stimulation of acid secretion in a resting stomach is normally associated with a decrease in transmucosal resistance. An increase in permeability to an ion may accordingly play a crucial role in the action of secretagogues. Stimulation may thus entail increased entry of K⁺, an ion known to be essential for acid secretion. In support of this argument are the findings that removal of K⁺ from the nutrient solution elevated resistance and …