Journal article
Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer
Abstract
DNA repair genes are commonly altered in metastatic prostate cancer, but BRCA1 mutations are rare. Preliminary studies suggest that higher tumor expression of the BRCA1 protein may be associated with worse prognosis. We undertook a prospective study among men with prostate cancer in the Health Professionals Follow-up Study and evaluated BRCA1 via immunohistochemical staining on tissue microarrays. BRCA1 was expressed in 60 of 589 tumors. …
Authors
Stopsack KH; Gerke T; Zareba P; Pettersson A; Chowdhury D; Ebot EM; Flavin R; Finn S; Kantoff PW; Stampfer MJ
Journal
Carcinogenesis, Vol. 41, No. 7, pp. 904–908
Publisher
Oxford University Press (OUP)
Publication Date
July 14, 2020
DOI
10.1093/carcin/bgaa061
ISSN
0143-3334