Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors

BackgroundSeizures after cardiac surgery are a serious complication. The antifibrinolytic agent tranexamic acid (TA), which has known proconvulsant properties, may be associated with postoperative seizures. We sought to determine the association between TA and other risk factors for seizures after cardiac surgery.Methods and resultsWe analyzed a database of consecutive cardiac surgery patients (April 2003 to December 2009) using multivariable …