Journal article
Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination
Abstract
BACKGROUND: Although high-dose (HD) vaccines have been reported to stimulate higher antibody responses compared with standard-dose (SD) influenza vaccines, there have been limited studies on the impact of frailty on such responses.
METHODS: We conducted a randomized, double-blind trial (2014/2015 to 2017/2018) of SD versus HD trivalent split-virus vaccine (Fluzone) in 612 study participants aged 65+ over 4 influenza seasons. Hemagglutination …
Authors
Loeb N; Andrew MK; Loeb M; Kuchel GA; Haynes L; McElhaney JE; Verschoor CP
Journal
Open Forum Infectious Diseases, Vol. 7, No. 5,
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2020
DOI
10.1093/ofid/ofaa148
ISSN
2328-8957