Journal article
Genotype-Positive Status in Patients With Hypertrophic Cardiomyopathy Is Associated With Higher Rates of Heart Failure Events
Abstract
BACKGROUND: The aim of the study was to clarify the relationship between genotype status and major cardiovascular outcomes in a large cohort of patients with hypertrophic cardiomyopathy.
METHODS AND RESULTS: Genetic testing was performed in 558 consecutive proband patients with hypertrophic cardiomyopathy. Baseline and follow-up (mean follow-up 6.3 years) clinical and echocardiographic data were obtained. Pathogenic mutations were identified in …
Authors
Li Q; Gruner C; Chan RH; Care M; Siminovitch K; Williams L; Woo A; Rakowski H
Journal
Circulation Genomic and Precision Medicine, Vol. 7, No. 4, pp. 416–422
Publisher
Wolters Kluwer
Publication Date
August 2014
DOI
10.1161/circgenetics.113.000331
ISSN
1942-325X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAge FactorsAgedCardiomyopathy, HypertrophicCarrier ProteinsCohort StudiesDeath, Sudden, CardiacEchocardiographyFemaleFollow-Up StudiesGenetic TestingGenotypeHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyosin Heavy ChainsPolymorphism, Single NucleotideProportional Hazards ModelsRisk FactorsSex Factors