Journal article
Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.
Abstract
Mast cells have been implicated in a number of diseases involving chronic inflammation including asthma, rheumatoid arthritis, and inflammatory bowel diseases. They are a potent source of several cytokines, including IL-6 and TNF-alpha. Freshly isolated rat peritoneal mast cells will produce IL-6 in response to anti-IgE, LPS, PGE1, or PGE2; however, the mechanisms by which such cytokine production is regulated are poorly understood. IL-10 is …
Authors
Marshall JS; Leal-Berumen I; Nielsen L; Glibetic M; Jordana M
Journal
Journal of Clinical Investigation, Vol. 97, No. 4, pp. 1122–1128
Publisher
American Society for Clinical Investigation
Publication Date
February 15, 1996
DOI
10.1172/jci118506
ISSN
0021-9738