Journal article
B7RP-1 Is Not Required for the Generation of Th2 Responses in a Model of Allergic Airway Inflammation but Is Essential for the Induction of Inhalation Tolerance
Abstract
The recently described ICOS-B7RP-1 costimulatory pathway has been implicated in the generation of effector Th2 responses and, hence, has become an attractive therapeutic target for allergic diseases. In the present study, we used B7RP-1-deficient mice to investigate the role of B7RP-1 in the generation and maintenance of Th2 responses in a model of mucosal allergic airway inflammation. We found that exposure of B7RP-1 knockout mice to …
Authors
Gajewska BU; Tafuri A; Świrski FK; Walker T; Johnson JR; Shea T; Shahinian A; Goncharova S; Mak TW; Stämpfli MR
Journal
The Journal of Immunology, Vol. 174, No. 5, pp. 3000–3005
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2005
DOI
10.4049/jimmunol.174.5.3000
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, InhalationAllergensAnimalsAntigens, Differentiation, T-LymphocyteB7-1 AntigenCD28 AntigensDisease Models, AnimalHumansImmune ToleranceImmunologic MemoryInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInflammationLungMiceMice, KnockoutOvalbuminRespiratory HypersensitivityRespiratory MucosaSignal TransductionTh2 Cells