Journal article
TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations.
Abstract
Airway remodeling is a characteristic feature of allergic asthma that is now thought to contribute to airway dysfunction and, ultimately, to clinical symptoms. A prevalent hypothesis holds that eosinophil-derived transforming growth factor-beta (TGF-beta) is a predominant underlying mechanism driving the development of remodeling and thus, represent promising targets for therapeutic intervention. This notion is supported by in vivo evidence …
Authors
Fattouh R; Jordana M
Journal
Inflammation & Allergy - Drug Targets, Vol. 7, No. 4, pp. 224–236
Publisher
Bentham Science Publishers
Publication Date
December 2008
DOI
10.2174/187152808786848388
ISSN
1871-5281