Review of fentanyl formulations in the management of breakthrough cancer pain

Breakthrough pain (BTP) has been commonly described as a transient exacerbation of pain that breaks through wellcontrolled persistent pain either spontaneously or in relation to a predictable trigger. The purpose was to summarize the evidence for dosing, frequency, definition of tolerance, and dose conversions between opioids in cancer patients administered various fentanyl ROO preparations. A literature search was conducted and 16 studies …