Journal article
Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE
Abstract
Severe disease caused by Shiga toxin-producing Escherichia coli (STEC) has been associated with a pathogenicity island, O-Island 122, which encodes the type III secretion system-effector NleE. Here we show that full virulence of the related attaching and effacing mouse pathogen Citrobacter rodentium requires NleE. Relative to wild-type bacteria, nleE-mutant C. rodentium are attenuated for colonisation in mice in both single and mixed …
Authors
Wickham ME; Lupp C; Vázquez A; Mascarenhas M; Coburn B; Coombes BK; Karmali MA; Puente JL; Deng W; Finlay BB
Journal
Microbes and Infection, Vol. 9, No. 3, pp. 400–407
Publisher
Elsevier
Publication Date
March 2007
DOI
10.1016/j.micinf.2006.12.016
ISSN
1286-4579