Journal article
Comparison of Aerosol and Intranasal Challenge in a Mouse Model of Allergic Airway Inflammation and Hyperresponsiveness
Abstract
BACKGROUND: The aim was to optimize antigen challenge for induction of airway hyperresponsiveness (AHR) and inflammation in BALB/c mice sensitized to ovalbumin (OVA). Comparisons were made between mice challenged with OVA either as an aerosol or intranasally. The protocol that induced maximal AHR in BALB/c mice was thereafter tested in C57BL/6 mice.
METHOD: Methacholine responsiveness was measured using the flexiVent® system to assess AHR. …
Authors
Swedin L; Ellis R; Kemi C; Ryrfeldt Å; Inman M; Dahlén S-E; Adner M
Journal
International Archives of Allergy and Immunology, Vol. 153, No. 3, pp. 249–258
Publisher
Karger Publishers
Publication Date
2010
DOI
10.1159/000314365
ISSN
1018-2438