Zinc compounds combined with cyclodextrin inhibit growth of Helicobacter pylori in-vitro

Zinc compounds have anti-gastric ulcer activity in animal models and in man. Since Helicobacter pylori is a major aetiologic agent in peptic ulcer disease this raised the possibility that part of the anti-ulcer activity of zinc could be due to its effects on the growth of H. pylori. We therefore investigated the in-vitro effects of zinc sulphate and a slow-release zinc compound, zinc monoglycerolate (ZMG), on the growth of H. pylori cultured in …