Journal article
Changes in rat and human pepsinogen phenotypes induced by N′‐methyl‐N′nitro‐n‐nitrosoguanidine
Abstract
Changes have been studied in human and rat pepsinogen phenotypes induced by N'-methyl-N'nitro-N-nitrosoguanidine (MMNG) in in vitro rat experiments and in vivo cultures of human and rat isolated gastric chief cells. In vivo the fastest migrating electrophoretic band decreased or disappeared as early as 3 weeks after the start of MNNG treatment. The changes, observed in 17 of 32 rats receiving MNNG, were permanent and consistently associated …
Authors
Defize J; Derodra JK; Riddell RH; Hunt RH
Journal
Cancer, Vol. 62, No. 9, pp. 1958–1961
Publisher
Wiley
Publication Date
November 1, 1988
DOI
10.1002/1097-0142(19881101)62:9<1958::aid-cncr2820620915>3.0.co;2-f
ISSN
1097-0142