Effects of non-steroidal anti-inflammatory drugs on prostaglandin h synthase isoenzyme 2 (cyclo-oxygenase 2) production by porcine gastric mucosa in organ culture

Considerable interest has been shown recently in the relative roles of the prostaglandin H synthase (PGHS) isoenzymes in the control of inflammation and the development of side-effects, especially those in the gastrointestinal (GI) tract, by non-steroidal anti-inflammatory drugs (NSAIDs). To examine the role of the PGHS isoenzymes in the development of prostaglandin-dependent gastric mucosal injury induced by NSAIDs, the distribution of …